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Fighting pain with Tramadol
Tramadol is an analgesic of central action. The drug reduces the reuptake of serotonin and norepinephrine in nerve cells and increases the serotonergic effect. Also, the drug has a mild sedative, antitussive effect.
Tramadol is a narcotic analgesic, often prescribed for moderate and moderately severe back pain in adults. Tramadol is a synthetic analogue of codeine with less risk of abuse than other opioid analogues, and has an effect directly on the human brain, changing the body’s response to pain.
In addition to getting rid of pain, Tramadol can cause mild euphoria. Although, it is classified as a drug (opioid), it is often referred to in the medical dictionary as “narcotic-like” because it is a synthetic drug with a slightly different structure than other drugs.
Tramadol is usually prescribed for one or two weeks to reduce the likelihood of addiction. In addition, the body quickly develops tolerance to Tramadol. So, the recommended dose of the drug becomes less effective over time. If the patients are older than 75 years, the doctor may advise to observe longer intervals between doses of the drug.
Like any medical drug, Tramadol has both positive and negative effects.
Tramadol is prescribed:
– for the treatment of acute / chronic pain syndrome (moderate or severe) or acute exacerbation of chronic pain (rheumatic pain, neuralgia, migraine, toothache, lumbago, back injuries, post-traumatic condition, vertebrogenic syndrome);
– during painful diagnostic / therapeutic interventions;
– in postoperative conditions accompanied by pain syndrome;
– pain syndrome due to malignant neoplasms.
You should not take Tramadol:
– in case of intolerance to the drug components;
– in the treatment of other opioid analgesics;
– in case of acute poisoning with central analgesics, antihypertensive agents, psychotropic drugs, alcohol;
– with uncontrolled form of epilepsy;
– while taking IMAO;
– during pregnancy / lactation;
– if you are a child under twelve years of age.
The reception during pregnancy and breast-feeding
Tramadol is not used in the period of breast-feeding or pregnancy.
Dosage and administration
Tramadol is used orally (by mouth).
The dosage is determined individually, depending on the intensity of the pain. The time interval between doses is from 6 to 12 hours.
Adults and children over 12 years old are usually prescribed 50 — 100 mg twice a day (morning and evening). The dose is allowed to increase to 150-200 mg twice a day.
The maximum daily dose-400 mg (in the amount per day)
Symptoms of overdose: vomiting, collapse, violation or loss of consciousness, convulsions, respiratory failure, depression of peristalsis.
Therapeutic measures: application of antidote (Naloxone), symptomatic therapy, artificial lung ventilation. Diazepam is taken in case of seizures. Hemodialysis is not enough for detoxification.
The drug is usually well tolerated, but, the following side effects may occur in the treatment of high doses.
General disorders: lethargy, sweating, dizziness.
Gastrointestinal disorders: nausea, dry mouth, feeling of heaviness in the stomach, changes in appetite, constipation, vomiting.
Neurological/mental disorders: headache, respiratory depression, drowsiness, tremor, impaired consciousness, activity (usually reduced, sometimes increased), decreased mental ability (impaired perception, decision-making), uncontrolled movements, mood changes, pupil dilation, hallucinations, seizures, physical / psychological dependence, withdrawal syndrome.
Dermatological reactions: exanthema, itching,
Cardiovascular disorders: tachycardia, tendency to collapse.
There should be some precautions during treatment with Tramadol: you should refuse to drive a car and perform potentially dangerous activities that require increased attention or speed of mental and motor reactions.
Patients with impaired liver or kidney drug treatment should start treatment with minimal doses. Special caution should be observed if Tramadol is prescribed to patients with drug and alcohol addiction.
More than 20 years of clinical experience in the use of Tramadol drugs in clinics worldwide indicates the compliance of the drug to modern requirements for a effective and safe drug to eliminate pain.